Endogenous reverse transcriptase as a mediator of ursolic acid's anti-proliferative and differentiating effects in human cancer cell lines

被引：61

作者：

Bonaccorsi, Irene ^{[1
]}

Altieri, Fabio ^{[2
]}

Sciamanna, Ilaria ^{[3
]}

Oricchio, Elisa ^{[3
]}

Grillo, Caterina

Contartese, Giuseppe ^{[1
]}

Galati, Enza Maria ^{[1
]}

机构：

[1] Univ Messina, Sch Pharm, Pharmaco Biol Dept, I-98168 Messina, Italy

[2] Univ Roma La Sapienza, Dept Biochem Sci A Rossi Fanelli, Rome, Italy

[3] Ist Super Sanita, I-00161 Rome, Italy

来源：

CANCER LETTERS | 2008年 / 263卷 / 01期

关键词：

ursolic acid; human tumor cell; reverse transcriptase; proliferation; differentiation;

D O I：

10.1016/j.canlet.2007.12.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ursolic acid (UA) is a pentacyclic triterpenoid compound that is widely distributed in the plant kingdom and has a broad range of biological effects. Here, we examined the effects of UA on the proliferation and differentiation of human tumor cell lines from melanoma (A375), glioblastoma (U87) and thyroid anaplastic carcinoma (ARO), and on the proliferation of a non-transformed human fibroblast cell line (WI-38). The results show that UA inhibits tumor cell proliferation in a dose- and time-dependent manner. Consistent with this finding, UA treatment promotes differentiation of all of the analyzed tumor cell lines. Interestingly, we found that UA inhibits the endogenous reverse transcriptase (RT) activity in tumor cells, which has recently been shown to be involved in the control of proliferation and differentiation of neoplastic cells. Considering these findings, we suggest that the observed anti-proliferative and differentiating effects of UA may be related to this target. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：130 / 139

页数：10

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