Intestinal Microbiota: A Regulator of Intestinal Inflammation and Cardiac Ischemia?

被引：14

作者：

Bashashati, Mohammad ^{[1
,2
,3
]}

Habibi, Hamid R. ^{[4
]}

Keshavarzian, Ali ^{[5
,6
]}

Schmulson, Max ^{[7
]}

Sharkey, Keith A. ^{[1
,2
]}

机构：

[1] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada

[2] Univ Calgary, Dept Physiol & Pharmacol, Snyder Inst Chron Dis, Calgary, AB, Canada

[3] Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Paul L Foster Sch Med, El Paso, TX 79905 USA

[4] Univ Calgary, Dept Cardiac Sci, Libin Cardiovasc Inst, Calgary, AB, Canada

[5] Rush Univ, Med Ctr, Div Digest Dis & Nutr, Chicago, IL 60612 USA

[6] Univ Utrecht, Div Pharmacol, Fac Sci, Utrecht Inst Pharmaceut Sci, Utrecht, Netherlands

[7] Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Lab Higado Pancreas & Motilidad HIPAM, Unidad Invest Med Expt,Fac Med, Mexico City, DF, Mexico

来源：

CURRENT DRUG TARGETS | 2015年 / 16卷 / 03期

关键词：

Coronary artery disease; gastrointestinal inflammation; inflammatory bowel disease; microbiota; trimethylamine N-oxide; CAUSE-SPECIFIC MORTALITY; CORONARY-HEART-DISEASE; HUMAN GUT MICROBIOTA; C-REACTIVE PROTEIN; FACTOR-V-LEIDEN; BOWEL-DISEASE; ULCERATIVE-COLITIS; CARDIOVASCULAR-DISEASE; PROTHROMBIN G20210A; CHROMOSOME; 9P21;

D O I：

10.2174/1389450116666150120104012

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Inflammatory bowel diseases (IBD) are chronic, relapsing and remitting gastrointestinal (GI) disorders of unknown etiology. IBD patients commonly exhibit extra-intestinal manifestations and complications of an inflammatory nature, presenting with disorders such as ankylosing spondylitis, uveitis and vasculitis. Although the metabolic syndrome is less prevalent in patients with IBD, they are at an increased risk for atherosclerosis and cardiovascular events. Considerable evidence supports the role of GI microbiota in the development of IBD. Recent studies have also shown a significant interaction between the metabolites of gut microbiota and the development of cardiovascular disease. Here we hypothesize that dysbiosis and/or abnormalities in the function of the intestinal microbiota promote cardiovascular disease in IBD patients, explaining the increased risk of cardiovascular events in these patients.

引用

页码：199 / 208

页数：10

共 109 条

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