In this paper we derive a lower bound on the error covariance matrix for any unbiased estimator of the parameters of a disturbance modeled as a mixture of spherically invariant random processes (SIRPs). The bound can be numerically computed in closed-form in many practical cases where the computation of the true Cramer-Rao lower bound is infeasible. The proposed bound is particularly useful when the disturbance, conditioned to a vector of unwanted random parameters (nuisance parameters) with a-priori known probability density function, can be modeled as a Gaussian process. The ease of disturbance composed of a mixture of K-distributed clutter, Gaussian clutter and thermal noise belongs to this set and it regards a realistic radar scenario. The performance of some practical estimators are compared to this bound for three study cases.