Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs delivered in pH-sensitive liposomes

被引：27

作者：

Düzgünes, N

Simoes, S

Slepushkin, V

Pretzer, E

Rossi, JJ

De Clercq, E

Antao, VP

Collins, ML

de Lima, MCP

机构：

[1] Univ Pacific, Dept Microbiol, San Francisco, CA 94115 USA

[2] Univ Coimbra, Pharmaceut Technol Lab, P-3000 Coimbra, Portugal

[3] Univ Coimbra, Ctr Neurosci, P-3000 Coimbra, Portugal

[4] Univ Coimbra, Dept Biochem, P-3000 Coimbra, Portugal

[5] Beckman Res Ctr City Hope, Dept Biol Mol, Duarte, CA 91010 USA

[6] Chiron Corp, Emeryville, CA 94608 USA

[7] Katholieke Univ Leuven, Rega Inst, Louvain, Belgium

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 4-7期

关键词：

D O I：

10.1081/NCN-100002327

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An antisense oligodeoxynucleotide against the human immunodeficiency virus type 1 (HIV-1) Rev response element, a ribozyme complementary to the HIV-1 5'-LTR, and the reverse transcriptase inhibitors 9-(2-phosphonylmethoxyethyl) adenine (PMEA) and(R)-9-(2-phosphonylmethoxypropyl)-adenine (PMPA) inhibited virus replication in monocyte-derived macrophages more effectively when delivered in pH-sensitive liposomes compared to the free drugs.

引用

页码：515 / 523

页数：9

共 39 条

[1] Anti-HIV therapy with antisense oligonucleotides and ribozymes: Realistic approaches or expensive myths? [J].