Effect of bupropion on sexual dysfunction

OBJECTIVE: To determine the role of bupropion in treatment of sexual dysfunction. DATA SOURCES: Studies and case reports were identified through MEDLINE (1970-July 2005) using search terms bupropion, antidepressants, sexual function, and sexual dysfunction. DATA SYNTHESIS: Bupropion has been shown to have a favorable effect on sexual dysfunction. Several reports and small, short-term trials have examined bupropion as an adjunct or substitute for other antidepressants in sexually dysfunctional patients. Use of bupropion has also been studied in nondepressed patients. Bupropion may be a promising medication for treating sexual dysfunction. However, specific dosing is unclear. CONCLUSIONS: While the studies reviewed here demonstrated some benefit in using bupropion to treat sexual dysfunction, limitations exist. Future studies should be conducted using larger sample sizes.