Hybrid virus-polymer materials. 1. Synthesis and properties of PEG-decorated cowpea mosaic virus

被引：200

作者：

Raja, KS

Wang, Q

Gonzalez, MJ

Manchester, M

Johnson, JE

Finn, MG

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[5] Scripps Res Inst, Ctr Integrat Mol Biosci, La Jolla, CA 92037 USA

来源：

BIOMACROMOLECULES | 2003年 / 4卷 / 03期

关键词：

D O I：

10.1021/bm025740+

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cowpea mosaic virus was derivatized with poly(ethylene glycol) to give well-controlled loadings of polymer on the outer surface of the coat protein assembly. The resulting conjugates displayed altered densities and immunogenicities, consistent with the known chemical and biological properties of PEG. These studies make CPMV potentially useful as a tailored vehicle for drug delivery.

引用

页码：472 / 476

页数：5

共 30 条

[1] Adenovirus complexed with polyethylene glycol and cationic lipid is shielded from neutralizing antibodies in vitro
Chillon, M
Lee, JH
Fasbender, A
Welsh, MJ
[J]. GENE THERAPY, 1998, 5 (07) : 995 - 1002
[2] PEGylation of E1-deleted adenovirus vectors allows significant gene expression on readministration to liver
Croyle, MA
Chirmule, N
Zhang, Y
Wilson, JM
[J]. HUMAN GENE THERAPY, 2002, 13 (15) : 1887 - 1900
[3] Development of a rapid method for the PEGylation of adenoviruses with enhanced transduction and improved stability under harsh storage conditions
Croyle, MA
Yu, QC
Wilson, JM
[J]. HUMAN GENE THERAPY, 2000, 11 (12) : 1713 - 1722
[4] DOGIC Z, 2000, PREPR ARCH CONDENS M, P1
[5] Host-guest encapsulation of materials by assembled virus protein cages
Douglas, T
Young, M
[J]. NATURE, 1998, 393 (6681) : 152 - 155
[6] Douglas T, 2002, ADV MATER, V14, P415, DOI 10.1002/1521-4095(20020318)14:6<415::AID-ADMA415>3.0.CO
[7] 2-W
[8] Douglas T, 1999, ADV MATER, V11, P679, DOI 10.1002/(SICI)1521-4095(199906)11:8<679::AID-ADMA679>3.0.CO
[9] 2-J
[10] FISHER D, 2000, POLYM PREPR, V41, P1012

← 1 2 3 →