Bone marrow and circulating stem/progenitor cells for regenerative cardiovascular therapy

被引：52

作者：

Alaiti, Mohamad Amer

Ishikawa, Masakazu

Costa, Marco A. ^{[1
]}

机构：

[1] Case Western Reserve Univ, Univ Hosp, Harrington McLaughlin Heart & Vasc Inst, Div Cardiovasc Med, Cleveland, OH 44106 USA

来源：

TRANSLATIONAL RESEARCH | 2010年 / 156卷 / 03期

关键词：

ENDOTHELIAL PROGENITOR CELLS; ACUTE MYOCARDIAL-INFARCTION; COLONY-STIMULATING FACTOR; CORONARY-ARTERY-DISEASE; LEFT-VENTRICULAR FUNCTION; HEMATOPOIETIC STEM-CELLS; BLOOD MONONUCLEAR-CELLS; CRITICAL LIMB ISCHEMIA; NITRIC-OXIDE SYNTHASE; PERIPHERAL-BLOOD;

D O I：

10.1016/j.trsl.2010.06.008

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Cardiovascular disease is the leading cause of death and disability in the Western world. In addition to the advancement of current therapeutic approaches to reduce the associated morbidity and mortality, regenerative medicine and cell-based therapy have been areas of continuous investigation. Circulating and bone-marrow-derived stem or endothelial progenitor cells are an attractive source for regenerative therapy in the cardiovascular field. In this review, we highlight the advantages and limitations of this approach with a focus on key observations from animal studies and clinical trials. (Translational Research 2010;156:112-129)

引用

页码：112 / 129

页数：18

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