Facile synthetic access to and biological evaluation of the macrocyclic core of apoptolidin

被引：29

作者：

Wender, PA ^{[1
]}

Jankowski, OD

Tabet, EA

Seto, H

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[2] Tokyo Univ Agr, Fac Appl Biosci, Dept Appl Biol & Chem, Tokyo, Japan

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 13期

关键词：

D O I：

10.1021/ol0346335

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Oxidative cleavage of the C-20/C-21 bond in apoptolidin (1) provides two fragments of similar complexity, facilitating a divide-and-diversify strategy for the determination of the structural basis for apoptolidin's biological activity, the remarkably selective induction of apoptosis in sensitive cell lines. The ability of compounds derived from this cleavage to inhibit mitochondrial F0F1-ATPase is reported.

引用

页码：2299 / 2302

页数：4

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