epsilon 4 allele of apolipoprotein E increases risk of Alzheimer's disease in a Chinese population

被引：57

作者：

Hong, CJ

Liu, TY

Liu, HC

Wang, SJ

Fuh, JL

Chi, CW

Lee, KY

Sim, CB

机构：

[1] VET GEN HOSP,INST NEUROL,TAIPEI,TAIWAN

[2] VET GEN HOSP,DEPT MED RES,TAIPEI 11217,TAIWAN

[3] VET GEN HOSP,DEPT PSYCHIAT,TAIPEI,TAIWAN

[4] NATL YANG MING UNIV,SCH MED,TAIPEI,TAIWAN

[5] TAIPEI MUNICIPAL YANG MING HOSP,TAIPEI,TAIWAN

来源：

NEUROLOGY | 1996年 / 46卷 / 06期

关键词：

D O I：

10.1212/WNL.46.6.1749

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined the apolipoprotein E genotype in 56 Chinese patients with late-onset sporadic Alzheimer's disease (AD) and 57 Chinese control subjects of similar age. The frequency of epsilon 4 in the AD group was significantly higher than that in the control group (23.2% versus 7.9%, p = 0.003). The odds ratio for AD in individuals with either one or two epsilon 4 was 2.96 (95% CI 1.11 to 8.03). The linear trend for AD in proportion to alleles of epsilon 4 was also significant (chi(2) = 8.2, p = 0.004). Our results support the association between epsilon 4 and AD in the Chinese.

引用

页码：1749 / 1751

页数：3

共 10 条

[1] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].