Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications

被引：435

作者：

Marcucci, Guido ^{[1
]}

Haferlach, Torsten

Doehner, Hartmut

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2011年 / 29卷 / 05期

关键词：

MICRORNA-EXPRESSION SIGNATURES; COMPLEX ABERRANT KARYOTYPE; TRANS-RETINOIC ACID; GROUP-B; CEBPA MUTATIONS; CANCER; AML; PREDICTS; IMPACT; TET2;

D O I：

10.1200/JCO.2010.30.2554

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Molecular analyses of leukemic blasts from patients with acute myeloid leukemia (AML) have revealed a striking heterogeneity with regard to the presence of acquired gene mutations and changes in gene and microRNA expression. Multiple submicroscopic genetic alterations with prognostic significance have been discovered. Application of gene- and microRNA profiling has identified genome-wide expression signatures that separate cytogenetic and molecular subsets of patients with AML into previously unrecognized biologic and/or prognostic subgroups. These and similar future findings are likely to have a major impact on the clinical management of AML because many of the identified genetic alterations not only represent independent prognosticators, but also may constitute targets for specific therapeutic intervention. In this report, we review genetic findings in AML and discuss their clinical implications. J Clin Oncol 29:475-486. (c) 2011 by American Society of Clinical Oncology

引用

页码：475 / 486

页数：12

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