Alveolar macrophage - T cell interactions during Th1-type sarcoid inflammation

被引:31
作者
Agostini, C
Facco, M
Chilosi, M
Semenzato, G
机构
[1] Univ Padua, Dip Med Clin & Sperimentale, Clin Immunol Branch, I-35128 Padua, Italy
[2] Univ Verona, Sch Med, Dept Pathol, I-35128 Padua, Italy
关键词
sarcoidosis; immunology; chemokines; cytokines;
D O I
10.1002/jemt.1094
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Sarcoidosis is an immunomediated, multisystem disorder of unknown cause(s) characterized by a heightened Th1 immune response that leads to an uncontrolled granuloma formation at sites of disease activity. The past few years have seen outstanding advances in the understanding of immunological and molecular events involved in the pathogenesis of this disease. The idea is that several cytokines and chemokines, which are secreted at sites of disease activity, participate in granuloma formation. This paper describes recent data that have clarified some of the events that govern the development of the hypersensitivity reaction during sarcoidosis. In particular, we will review recent evidence indicating that a complex relationship exists between the macrophage/lymphocyte cellular axis and the tissue networks of cytokines. (C) 2001 Wiley-Liss, Inc.
引用
收藏
页码:278 / 287
页数:10
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