Neutrophils in cancer: neutral no more

被引：1702

作者：

Coffelt, Seth B. ^{[1
]}

Wellenstein, Max D. ^{[1
]}

de Visser, Karin E. ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Immunol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands

来源：

NATURE REVIEWS CANCER | 2016年 / 16卷 / 07期

基金：

欧洲研究理事会;

关键词：

COLONY-STIMULATING FACTOR; TUMOR-ASSOCIATED NEUTROPHILS; INFLAMMATION-ASSOCIATED CARCINOGENESIS; CHEMOTHERAPY-INDUCED NEUTROPENIA; GR-1+CD11B+ MYELOID CELLS; ANTI-VEGF THERAPY; BONE-MARROW; SUPPRESSOR-CELLS; G-CSF; HEMATOPOIETIC STEM;

D O I：

10.1038/nrc.2016.52

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Neutrophils are indispensable antagonists of microbial infection and facilitators of wound healing. In the cancer setting, a newfound appreciation for neutrophils has come into view. The traditionally held belief that neutrophils are inert bystanders is being challenged by the recent literature. Emerging evidence indicates that tumours manipulate neutrophils, sometimes early in their differentiation process, to create diverse phenotypic and functional polarization states able to alter tumour behaviour. In this Review, we discuss the involvement of neutrophils in cancer initiation and progression, and their potential as clinical biomarkers and therapeutic targets.

引用

页码：431 / 446

页数：16

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