Interleukin 2: from immunostimulation to immunoregulation and back again

被引：224

作者：

Bachmann, Martin F. ^{[1
]}

Oxenius, Annette ^{[2
]}

机构：

[1] Cytos Biotechnol AG, CH-8952 Zurich, Switzerland

[2] ETH Honggerberg, Inst Microbiol, Swiss Fed Inst Technol, CH-8093 Zurich, Switzerland

来源：

EMBO REPORTS | 2007年 / 8卷 / 12期

关键词：

adaptive immunity; immune regulation; immune stimulation; interleukin; 2; T lymphocyte;

D O I：

10.1038/sj.embor.7401099

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Interleukin 2 (IL-2) was one of the first cytokines to be discovered. However, the complex role of IL-2 and its receptor in the regulation of immune responses is only now emerging. This review explores the various signals triggered by IL-2 and discusses their translation into biological function. A model is outlined that accommodates the seemingly contradictory functions of IL-2, and explains how one cytokine can be an essential T-cell growth and differentiation factor and yet also be indispensable to maintain peripheral tolerance.

引用

收藏

页码：1142 / 1148

页数：7

相关论文

共 84 条

[1]

The control of T cell activation vs. tolerance [J].

Abbas, AK .

AUTOIMMUNITY REVIEWS, 2003, 2 (03) :115-118

[2]

Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection [J].

Agnellini, Paola ;

Wolint, Petra ;

Rehr, Manuela ;

Cahenzli, Julia ;

Karrer, Urs ;

Oxenius, Annette .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (11) :4565-4570

[3]

Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections [J].

Bachmann, Martin F. ;

Wolint, Petra ;

Walton, Senta ;

Schwarz, Katrin ;

Oxenius, Annette .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (06) :1502-1512

[4]

Recall proliferation potential of memory CD8+ T cells and antiviral protection [J].

Bachmann, MF ;

Wolint, P ;

Schwarz, K ;

Oxenius, A .

JOURNAL OF IMMUNOLOGY, 2005, 175 (07) :4677-4685

[5]

Cutting edge:: Distinct roles for T help and CD40/CD40 ligand in regulating differentiation of proliferation-competent memory CD8+ T cells [J].

Bachmann, MF ;

Schwarz, K ;

Wolint, P ;

Meijerink, E ;

Martin, S ;

Manolova, V ;

Oxenius, A .

JOURNAL OF IMMUNOLOGY, 2004, 173 (04) :2217-2221

[6]

Balancing protective immunity and immunopathology [J].

Bachmann, MF ;

Kopf, M .

CURRENT OPINION IN IMMUNOLOGY, 2002, 14 (04) :413-419

[7]

ANTIVIRAL IMMUNE-RESPONSES IN MICE DEFICIENT FOR BOTH INTERLEUKIN-2 AND INTERLEUKIN-4 [J].

BACHMANN, MF ;

SCHORLE, H ;

KUHN, R ;

MULLER, W ;

HENGARTNER, H ;

ZINKERNAGEL, RM ;

HORAK, I .

JOURNAL OF VIROLOGY, 1995, 69 (08) :4842-4846

[8]

THE INTERLEUKIN (IL)-2 RECEPTOR-BETA CHAIN IS SHARED BY IL-2 AND A CYTOKINE, PROVISIONALLY DESIGNATED IL-T, THAT STIMULATES T-CELL PROLIFERATION AND THE INDUCTION OF LYMPHOKINE-ACTIVATED KILLER-CELLS [J].

BAMFORD, RN ;

GRANT, AJ ;

BURTON, JD ;

PETERS, C ;

KURYS, G ;

GOLDMAN, CK ;

BRENNAN, J ;

ROESSLER, E ;

WALDMANN, TA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4940-4944

[9]

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo [J].

Blattman, JN ;

Grayson, JM ;

Wherry, EJ ;

Kaech, SM ;

Smith, KA ;

Ahmed, R .

NATURE MEDICINE, 2003, 9 (05) :540-547

[10]

Selective stimulation of T cell subsets with antibody-cytokine immune complexes [J].

Boyman, O ;

Kovar, M ;

Rubinstein, MP ;

Surh, CD ;

Sprent, J .

SCIENCE, 2006, 311 (5769) :1924-1927

← 1 2 3 4 5 6 7 8 9 →