Anti-C1q Antibodies as a Follow-Up Marker in SLE Patients

被引：42

作者：

Bock, Merete ^{[1
]}

Heijnen, Ingmar ^{[2
]}

Trendelenburg, Marten ^{[1
]}

机构：

[1] Univ Basel Hosp, Div Internal Med, CH-4031 Basel, Switzerland

[2] Univ Basel Hosp, Dept Lab Med, Div Med Immunol, CH-4031 Basel, Switzerland

来源：

PLOS ONE | 2015年 / 10卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; HEREDITARY C1Q DEFICIENCY; DISEASE-ACTIVITY; IGG AUTOANTIBODIES; PREDICTIVE-VALUE; NEPHRITIS; COMPLEMENT; HYPOCOMPLEMENTEMIA; MANIFESTATIONS; IMMUNOLOGY;

D O I：

10.1371/journal.pone.0123572

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

In cross-sectional studies autoantibodies against complement C1q (anti-C1q) were found to be highly associated with active lupus nephritis. The aim of this retrospective study was to determine the value of anti-C1q as follow-up marker of disease activity and renal involvement in patients with systemic lupus erythematosus (SLE). Fifty-two patients with SLE and a minimum of three anti-C1q measurements during follow-up were analyzed. Anti-C1q levels correlated with global disease activity scores. In subgroup analyses, patients without renal involvement did not show a significant correlation between anti-C1q levels and disease activity. In contrast, in patients with renal involvement, anti-C1q levels correlated well with global disease activity. In addition, a positive correlation with the urine protein-to-creatinine ratio and anti-dsDNA antibody levels as well as a negative correlation with complement levels was observed. Anti-C1q antibodies were found to strongly correlate with parameters of SLE disease activity during follow-up, in particular with regard to renal involvement.

引用

页数：11

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