Transmission of HCV in HIV-positive populations

被引:48
作者
Danta, Mark [1 ]
Rodger, Alison J. [2 ]
机构
[1] Univ New S Wales, Fac Med, St Vincents Clin Sch, Sydney, NSW, Australia
[2] UCL, Royal Free & Univ Coll Med Sch, Dept HIV Med, London, England
基金
澳大利亚国家健康与医学研究理事会;
关键词
acute hepatitis C; co-infection; epidemiology; hepatitis C virus; HIV; transmission; HEPATITIS-C VIRUS; SEXUAL TRANSMISSION; INFECTED MEN; HOMOSEXUAL-MEN; SUBSTANCE USE; COHORT; INCREASE; RISK; MSM; BALTIMORE;
D O I
10.1097/COH.0b013e32834b4974
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
Purpose of review The epidemiology of hepatitis C virus (HCV) in HIV has changed significantly over the past decade. This review will outline the current epidemiology of HCV in HIV infection, focusing on the recent changes and factors which have been related to the increase in HCV transmission in HIV-infected men who have sex with men (MSM). Recent findings Since 2000 there has been recognition in the postindustrialized world that there has been a dramatic rise in the incidence of HCV in HIV-infected MSM. Whereas sexual transmission of HCV remains controversial in the general population, there is increasing evidence that permucosal (sexual and mucosally administered drugs) rather than parenteral risks have become key factors in HCV transmission in HIV-infected MSM. At the most basic level, transmission depends on disruption of a barrier and exposure to infected fluids, usually blood. Whereas transmission factors are often closely entwined, they can be characterized as behavioural and biological factors. Summary With an improved understanding of the epidemiology of HCV in this population, interventions by relevant health authorities could be better focused.
引用
收藏
页码:451 / 458
页数:8
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