Poisson-Nernst-Planck theory approach to the calculation of current through biological ion channels

被引：101

作者：

Coalson, RD ^{[1
]}

Kurnikova, MG

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15213 USA

[2] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA

来源：

IEEE TRANSACTIONS ON NANOBIOSCIENCE | 2005年 / 4卷 / 01期

关键词：

biological system modeling; biomembranes; dielectric liquids; finite difference methods; potential of mean force; protein fluctuations;

D O I：

10.1109/TNB.2004.842495

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The Poisson-Nernst-Planck (PNP) theory of electro-diffusion is reviewed. Techniques for numerical solution of the three-dimensional PNP equations are summarized, and several illustrative applications to ion transport through protein channels are presented. Strengths and weaknesses of the theory are discussed, as well as attempts to improve it via increasingly realistic evaluation of the force acting on each ion due to the protein/membrane environment.

引用

页码：81 / 93

页数：13

共 59 条

[1] Energetics of ion conduction through the gramicidin channel [J].

Allen, TW ;

Andersen, OS ;

Roux, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (01) :117-122

[2]

AQUIST J, 1990, J PHYS CHEM-US, V94, P8021

[3]

ARSENIEV AS, 1986, BIOL MEMBRANY, V3, P1077

[4] Ion flow through narrow membrane channels: part II [J].

Barcilon, Victor ;

Chen, D.-P. ;

Eisenberg, R.S. .

SIAM Journal on Applied Mathematics, 1992, 52 (05) :1405-1425

[5]

Beck TL, 1997, INT J QUANTUM CHEM, V65, P477, DOI 10.1002/(SICI)1097-461X(1997)65:5<477::AID-QUA12>3.0.CO

[6]

2-0

[7]

Bockris J.OM., 1998, MODERN ELECTROCHEMIS, V1

[8]

BURYKIN A, 2002, PROTEIN-STRUCT FUNCT, V43, P265

[9] Noncontact dipole effects on channel permeation.: I.: Experiments with (5F-Indole)Trp13 gramicidin A channels [J].

Busath, DD ;

Thulin, CD ;

Hendershot, RW ;

Phillips, LR ;

Maughan, P ;

Cole, CD ;

Bingham, NC ;

Morrison, S ;

Baird, LC ;

Hendershot, RJ ;

Cotten, M ;

Cross, TA .

BIOPHYSICAL JOURNAL, 1998, 75 (06) :2830-2844

[10] Three-dimensional Poisson-Nernst-Planck theory studies:: Influence of membrane electrostatics on gramicidin A channel conductance [J].

Cárdenas, AE ;

Coalson, RD ;

Kurnikova, MG .

BIOPHYSICAL JOURNAL, 2000, 79 (01) :80-93

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