Calmodulin kinase signaling in heart: an intriguing candidate target for therapy of myocardial dysfunction and arrhythmias

被引：103

作者：

Anderson, ME ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Nashville, TN 37232 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2005年 / 106卷 / 01期

基金：

美国国家卫生研究院;

关键词：

calmodulin kinase; arrhythmia; sudden death; cellular calcium; structural heart disease; electrophysiology;

D O I：

10.1016/j.pharmthera.2004.11.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The multifunctional Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) has emerged as a proarrhythmic and procardiornyopathic signal in a wide range of structural heart diseases. This review discusses CaMKII structure and function and recent evidence implicating CaMKII inhibition as a potential strategy for treating myocardial dysfunction and arrhythmias in the setting of structural heart disease. (c) 2004 Elsevier Inc. All rights reserved.

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收藏

页码：39 / 55

页数：17

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