3,28-di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents

被引：48

作者：

Kashiwada, Y

Chiyo, J

Ikeshiro, Y

Nagao, T

Okabe, H

Cosentino, LM

Fowke, K

Lee, KH

机构：

[1] Niigata Coll Pharm, Niigata 9502081, Japan

[2] Fukuoka Univ, Fac Pharmaceut Sci, Fukuoka 8140180, Japan

[3] BBI Biotech Res Labs, Gaithersburg, MD 20877 USA

[4] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(00)00635-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four isomers of 3,28-di-O-(dimethylsuccinyl)-betulin were prepared and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 3-O-(3', 3'-Dimethylsuccinyl)-28-O-(2", 2"-dimethylsuccinyl)-betulin (11) was the most potent anti-HIV compound with an EC50 value of 0.00087 muM and a TI value of 42,400. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：183 / 185

页数：3

共 5 条

[1] ANTI-AIDS AGENTS .11. BETULINIC ACID AND PLATANIC ACID AS ANTI-HIV PRINCIPLES FROM SYZIGIUM-CLAVIFLORUM, AND THE ANTI-HIV ACTIVITY OF STRUCTURALLY RELATED TRITERPENOIDS [J].