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Going the distance: A current view of enhancer action

被引：605
作者：
Blackwood, EM
Kadonaga, JT [1 ]
机构：
[1] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Ctr Mol Genet, La Jolla, CA 92093 USA
来源：
SCIENCE | 1998年 / 281卷 / 5373期
关键词：
D O I：
10.1126/science.281.5373.60
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In eukaryotes, transcription of genes by RNA polymerase II yields messenger RNA intermediates from which protein products are synthesized. Transcriptional enhancers are discrete DNA elements that contain specific sequence motifs with which DNA-binding proteins interact and transmit molecular signals to genes. it Here, current models regarding the role of enhancers in the regulation of transcription !I by RNA polymerase II are presented.
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页码：60 / 63
页数：4
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