Characterisation of a bovine/murine hybrid cell panel informative for all bovine autosomes

被引：12

作者：

Konfortov, BA

Jorgensen, CB

Miller, JR

Tucker, EM

机构：

[1] Babraham Inst, Dept Immunol, Lab Genome Mapping, Cambridge CB2 4AT, England

[2] Royal Vet & Agr Univ, Dept Anim Sci, Div Anim Genet, DK-1870 Frederiksberg C, Denmark

来源：

ANIMAL GENETICS | 1998年 / 29卷 / 04期

关键词：

bovine/murine hybrid cell panel; genome mapping; synteny mapping;

D O I：

10.1046/j.1365-2052.1998.00336.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

A bovine/murine hybrid cell panel consisting of 57 cell lines was typed with 124 markers by PCR, Southern hybridisation and isozyme analysis in order to establish its utility as a resource for genome mapping. All bovine chromosomes, including the sex chromosomes were represented in the panel. Computerised analysis of syntenies indicated that there are no cell lines containing only a single bovine chromosome. The panel was used to map 10 new bovine microsatellite markers, and the MYL6 and CPE genes. This panel is informative for all bovine chromosomes other than the sex-specific region of the X chromosome and can be used in synteny mapping studies. At present, due to the relatively small number of markers typed, the resolution of the panel does not go beyond the chromosomal level.

引用

页码：302 / 306

页数：5

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