Optimisation of cyclotron production parameters for the 209Bi(α, 2n) 211At reaction related to biomedical use of 211At

被引：43

作者：

Henriksen, G

Messelt, S

Olsen, E

Larsen, RH

机构：

[1] Univ Oslo, Dept Chem, N-0315 Oslo, Norway

[2] ATI AS, N-0314 Oslo, Norway

[3] Univ Oslo, Dept Phys, N-0315 Oslo, Norway

来源：

APPLIED RADIATION AND ISOTOPES | 2001年 / 54卷 / 05期

关键词：

At-210; At-211; Po-210; alpha emitters; energy calibration; beam optimisation;

D O I：

10.1016/S0969-8043(00)00346-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The cyclotron alpha beam production of At-211 and of the contaminant At-210 related to beam energy were studied. Radiochemical purification of At-211 from the other main contaminant, Po-210, by an extraction procedure was also evaluated. To avoid impurities 28 MeV has previously been considered as a maximum beam energy, but by using instead 29.1 MeV as a limit a large increase in EOB yield and sufficient radiochemical purity of extracted At-211 were obtained. More cyclotrons could thereby deliver quantities useful for clinical cancer trials. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：839 / 844

页数：6

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