Galleria mellonella are Resistant to Pneumocystis murina Infection

被引：9

作者：

Fuchs, Beth Burgwyn ^{[1
]}

Bishop, Lisa R. ^{[2
]}

Kovacs, Joseph A. ^{[2
]}

Mylonakis, Eleftherios ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

[2] NIH, Dept Crit Care Med, Ctr Clin, Bethesda, MD 20892 USA

来源：

MYCOPATHOLOGIA | 2011年 / 171卷 / 04期

关键词：

Galleria mellonella; Infection model; Pneumocystis murina; IMMUNE-RESPONSE; CARINII; VIRULENCE; LARVAE; MODEL; MICE; PATHOGENICITY; EXPRESSION;

D O I：

10.1007/s11046-010-9368-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Studying Pneumocystis has proven to be a challenge from the perspective of propagating a significant amount of the pathogen in a facile manner. The study of several fungal pathogens has been aided by the use of invertebrate model hosts. Our efforts to infect the invertebrate larvae Galleria mellonella with Pneumocystis proved futile since P. murina neither caused disease nor was able to proliferate within G. mellonella. It did, however, show that the pathogen could be rapidly cleared from the host.

引用

页码：273 / 277

页数：5

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