Regulation of Listeria virulence: PrfA master and commander

被引：206

作者：

de las Heras, Aitor ^{[1
,2
]}

Cain, Robert J. ^{[1
,2
]}

Bielecka, Magdalena K. ^{[1
,2
]}

Vazquez-Boland, Jose A. ^{[1
,2
,3
]}

机构：

[1] Univ Edinburgh, Microbial Pathogenesis Unit, Ctr Infect Dis & Immun, Sch Biomed Sci, Edinburgh EH9 3JT, Midlothian, Scotland

[2] Univ Edinburgh, Sch Biomed Sci, Ctr Infect & Evolut, Edinburgh EH9 3JT, Midlothian, Scotland

[3] Univ Leon, Fac Vet, Grp Patogen Bacteriana, E-24071 Leon, Spain

来源：

CURRENT OPINION IN MICROBIOLOGY | 2011年 / 14卷 / 02期

基金：

英国惠康基金;

关键词：

IN-VITRO TRANSCRIPTION; SIGMA-B CONTRIBUTES; TO-CELL SPREAD; MONOCYTOGENES VIRULENCE; GENE-EXPRESSION; STRESS TOLERANCE; BACTERIAL VIRULENCE; MEDIATED VIRULENCE; BINDING-AFFINITY; CULTURE-MEDIA;

D O I：

10.1016/j.mib.2011.01.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Listeria monocytogenes is the causative agent of listeriosis, a severe foodborne infection. These bacteria live as soil saprotrophs on decaying plant matter but also as intracellular parasites, using the cell cytosol as a replication niche. PrfA, a regulatory protein, integrates a number of environmental cues that signal the transition between these two contrasting lifestyles, activating a set of key virulence factors during host infection. While a number of details concerning the general mode of action of this virulence master switch have been elucidated, others remain unsolved. Recent work has revealed additional mechanisms that contribute to L. monocytogenes virulence modulation, often via cross-talk with PrfA, or by regulating new genes involved in host colonization.

引用

收藏

页码：118 / 127

页数：10

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