The IL-1 cytokine family and its role in inflammation and fibrosis in the lung

被引：257

作者：

Borthwick, L. A. ^{[1
]}

机构：

[1] Newcastle Univ, Inst Cellular Med, Fibrosis Res Grp, 4th Floor,William Leech Bldg, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2016年 / 38卷 / 04期

关键词：

IL-1; IL-18; IL-33; Fibroblast; Inflammation; Fibrosis; Lung; OBSTRUCTIVE PULMONARY-DISEASE; INTERLEUKIN-1 RECEPTOR ANTAGONIST; ALLERGIC AIRWAY INFLAMMATION; NF-KAPPA-B; BRONCHIAL EPITHELIAL-CELLS; NECROSIS-FACTOR-ALPHA; GAMMA-INDUCING FACTOR; COLLAGEN-INDUCED ARTHRITIS; MESSENGER-RNA EXPRESSION; HUMAN LEUKOCYTIC PYROGEN;

D O I：

10.1007/s00281-016-0559-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of inflammation and fibrosis in multiple tissues including the lung. IL-1 targeted therapies have been successfully employed to treat a range of inflammatory conditions such as rheumatoid arthritis and gouty arthritis. This review will introduce the members of the IL-1 cytokine family, briefly discuss the cellular origins and cellular targets and provide an overview of the role of these molecules in inflammation and fibrosis in the lung.

引用

页码：517 / 534

页数：18

共 250 条

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