1,2-asymmetric induction in dianionic-allylation reactions of amino acid derivatives-synthesis of functionally useful, enantiopure aspartates and constrained scaffolds.

被引：25

作者：

Hanessian, S ^{[1
]}

Margarita, R ^{[1
]}

Hall, A ^{[1
]}

Luo, XH ^{[1
]}

机构：

[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 33期

关键词：

allylation; asymmetric induction; amino acids and derivatives; peptide analogs/mimetics;

D O I：

10.1016/S0040-4039(98)00899-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dianions derived from N-Cbz aspartic acid esters undergo highly stereoselective anti allylation reactions at the unsubstituted carbon. The roles of additives, of the cation and of the electrophile were studied; Synthetic applications and potential utility in peptidomimetic design are also described. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5883 / 5886

页数：4

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