Fish consumption is associated with lower heart rates

被引:98
作者
Dallongeville, J
Yarnell, J
Ducimetière, P
Arveiler, D
Ferrières, J
Montaye, M
Luc, G
Evans, A
Bingham, A
Hass, B
Ruidavets, JB
Amouyel, P
机构
[1] Inst Pasteur, INSERM, U508, F-59019 Lille, France
[2] Queens Univ Belfast, Dept Epidemiol & Publ Hlth, Belfast, Antrim, North Ireland
[3] Hop Paul Brousse, INSERM, U258, Villejuif, France
[4] Lab Epidemiol & Sante Publ, Strasbourg, France
[5] Fac Med Purpan, INSERM, U558, Toulouse, France
关键词
nutrition; heart rate; fatty acids; death; sudden;
D O I
10.1161/01.CIR.0000084542.64687.97
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background-Fish consumption decreases risk of sudden death. The goal of the present study was to assess the relationship between fish consumption and heart rate. Methods and Results-A cross-sectional analysis was conducted of 9758 men, age 50 to 59 years, without coronary heart disease (CHD) who were recruited in France and Belfast, Ireland, from 1991 to 1993. Heart rate and CHD risk factors were compared among 4 categories of fish consumption, as follows: (1) less than once per week (n=2662), (2) once per week (n=4576), (3) twice per week (n=1964), and (4) more than twice per week (n=556). Fatty acid profiles of erythrocyte phospholipids were determined in a random subsample of 407 subjects. In erythrocyte phospholipids, eicosapentaenoic acid (P<0.0005), docosahexaenoic acid (P<0.0001), and total n-3 fatty acid (P<0.0008) increased across the categories of fish intake. Triglycerides (P<0.0001), systolic blood pressure (P<0.006), and diastolic blood pressure (P<0.0001) were lower and HDL cholesterol levels (P<0.004) were higher in fish consumers than in nonconsumers. Similarly, heart rate decreased across the categories of fish intake (P<0.0001). After adjustment for age, center, education level, physical activity, smoking habit, alcohol consumption, body mass index, and antiarrhythmic medications, heart rate remained statistically lower among fish consumers than among nonconsumers (P for trend<0.0001). Docosahexaenoic acid content of erythrocyte phospholipids was inversely correlated with heart rate (P<0.03). Conclusions-Fish consumption is associated with decreased heart rate in men. Because heart rate is positively associated with risk of sudden death, this association may explain, at least in part, the lower risk of sudden death among fish consumers.
引用
收藏
页码:820 / 825
页数:6
相关论文
共 33 条
[1]   Blood levels of long-chain n-3 fatty acids and the risk of sudden death. [J].
Albert, CM ;
Campos, H ;
Stampfer, MJ ;
Ridker, PM ;
Manson, JE ;
Willett, WC ;
Ma, J .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (15) :1113-1118
[2]   Fish consumption and risk of sudden cardiac death [J].
Albert, CM ;
Hennekens, CH ;
O'Donnell, CJ ;
Ajani, UA ;
Carey, VJ ;
Willett, WC ;
Ruskin, JN ;
Manson, JE .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (01) :23-28
[3]  
[Anonymous], 1982, MINNESOTA CODE RESTI
[4]   Prevention of ischemia-induced cardiac sudden death by n-3 polyunsaturated fatty acids in dogs [J].
Billman, GE ;
Kang, JX ;
Leaf, A .
LIPIDS, 1997, 32 (11) :1161-1168
[5]   Prevention of sudden cardiac death by dietary pure ω-3 polyunsaturated fatty acids in dogs [J].
Billman, GE ;
Kang, JX ;
Leaf, A .
CIRCULATION, 1999, 99 (18) :2452-2457
[6]   Association between n-3 fatty acid status in blood and electrocardiographic in predictors of arrhythmia risk healthy volunteers [J].
Brouwer, IA ;
Zock, PL ;
van Amelsvoort, LGPM ;
Katan, MB ;
Schouten, EG .
AMERICAN JOURNAL OF CARDIOLOGY, 2002, 89 (05) :629-+
[7]  
BURR ML, 1989, LANCET, V2, P757
[8]  
Christensen JH, 1996, BMJ-BRIT MED J, V312, P677, DOI 10.1136/bmj.312.7032.677
[9]   Fish consumption, n-3 fatty acids in cell membranes, and heart rate variability in survivors of myocardial infarction with left ventricular dysfunction [J].
Christensen, JH ;
Korup, E ;
Aaroe, J ;
Toft, E ;
Moller, J ;
Rasmussen, K ;
Dyerberg, J ;
Schmidt, EB .
AMERICAN JOURNAL OF CARDIOLOGY, 1997, 79 (12) :1670-+
[10]  
Christensen JH, 1999, AM J CLIN NUTR, V70, P331