The Roles of Type I Interferon in Bacterial Infection

被引：287

作者：

Boxx, Gayle M. ^{[1
]}

Cheng, Genhong ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

来源：

CELL HOST & MICROBE | 2016年 / 19卷 / 06期

关键词：

GMP-AMP SYNTHASE; MYCOBACTERIUM-TUBERCULOSIS; LISTERIA-MONOCYTOGENES; IFN-GAMMA; RNASE-L; ENHANCES SUSCEPTIBILITY; FRANCISELLA INFECTION; HOST-DEFENSE; DNA SENSOR; RIG-I;

D O I：

10.1016/j.chom.2016.05.016

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Type I interferons (IFNs) are pleiotropic cytokines well recognized for their role in the induction of a potent antiviral gene program essential for host defense against viruses. They also modulate innate and adaptive immune responses. However, the role of type I IFNs in host defense against bacterial infections is enigmatic. Depending on the bacterium, they exert seemingly opposite and capricious functions. In this review, we summarize the effect of type I IFNs on specific bacterial infections and highlight the effector mechanisms regulated by type I IFNs in an attempt to elucidate new avenues to understanding their role.

引用

页码：760 / 769

页数：10

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