Sildenafil as a treatment for pulmonary hypertension

被引:41
作者
Carroll, WD
Dhillon, R
机构
[1] Birmingham Childrens Hosp, Dept Cardiol, Birmingham B4 6NH, W Midlands, England
[2] Birmingham Childrens Hosp, Dept Resp Med, Birmingham B4 6NH, W Midlands, England
关键词
D O I
10.1136/adc.88.9.827
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Severe, chronic pulmonary hypertension in childhood is uncommon, difficult to treat, and carries a poor prognosis. Sildenafil (Viagra, Pfizer) has been used successfully in adults with pulmonary hypertension as monotherapy or in combination with inhaled prostacyclin. Here we report on its use in three children.
引用
收藏
页码:827 / 828
页数:2
相关论文
共 9 条
[1]  
Abrams D, 2000, Heart, V84, pE4, DOI 10.1136/heart.84.2.e4
[2]   Vasodilator therapy for primary pulmonary hypertension in children [J].
Barst, RJ ;
Maislin, G ;
Fishman, AP .
CIRCULATION, 1999, 99 (09) :1197-1208
[3]   Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension - Open-label pilot study [J].
Barst, RJ ;
Rich, S ;
Widlitz, A ;
Horn, EM ;
McLaughlin, V ;
McFarlin, J .
CHEST, 2002, 121 (06) :1860-1868
[4]   A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension [J].
Barst, RJ ;
Rubin, LJ ;
Long, WA ;
McGoon, MD ;
Rich, S ;
Badesch, DB ;
Groves, BM ;
Tapson, VF ;
Bourge, RC ;
Brundage, BH ;
Koerner, SK ;
Langleben, D ;
Keller, CA ;
Murali, S ;
Uretsky, BF ;
Clayton, LM ;
Jobsis, MM ;
Blackburn, SD ;
Shortino, D ;
Crow, JW .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (05) :296-301
[5]   Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension [J].
Ghofrani, HA ;
Wiedemann, R ;
Rose, F ;
Olschewski, H ;
Schermuly, RT ;
Weissmann, N ;
Seeger, W ;
Grimminger, F .
ANNALS OF INTERNAL MEDICINE, 2002, 136 (07) :515-522
[6]  
Gibbs JSR, 2001, HEART, V86, pI1
[7]   Sildenafil in primary pulmonary hypertension. [J].
Prasad, S ;
Wilkinson, J ;
Gatzoulis, MA .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (18) :1342-1342
[8]   Bosentan therapy for pulmonary arterial hypertension [J].
Rubin, LJ ;
Badesch, DB ;
Barst, RJ ;
Galiè, N ;
Black, CM ;
Keogh, A ;
Pulido, T ;
Frost, A ;
Roux, S ;
Leconte, I ;
Landzberg, M ;
Simonneau, G .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (12) :896-903
[9]   Sildenafil inhibits hypoxia-induced pulmonary hypertension [J].
Zhao, L ;
Mason, NA ;
Morrell, NW ;
Kojonazarov, B ;
Sadykov, A ;
Maripov, A ;
Mirrakhimov, MM ;
Aldashev, A ;
Wilkins, MR .
CIRCULATION, 2001, 104 (04) :424-428