A new human immunodeficiency virus type 1 circulating recombinant form from Tanzania

被引:46
作者
Koulinska, IN
Ndung'u, T
Mwakagile, D
Msamanga, G
Kagoma, C
Fawzi, W
Essex, M
Renjifo, B
机构
[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Harvard AIDS Inst, Boston, MA 02115 USA
[3] Muhimbili Med Ctr, Dept Microbiol & Immunol, Dar Es Salaam, Tanzania
[4] Muhimbili Med Ctr, Dept Community Hlth, Dar Es Salaam, Tanzania
[5] Harvard Univ, Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA 02215 USA
关键词
D O I
10.1089/088922201750102508
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
It is becoming increasingly important to identify and to study human immunodeficiency virus type 1 (HIV-1) circulating recombinant forms (CRFs) with evidence of epidemic spread, since mosaic strains arise frequently, especially in populations where multiple subtypes cocirculate. We describe the almost complete nucleotide sequence of 3 subtype C and D recombinant viruses, selected from a pool of 13 D(gag)-D/C/D(env) perinatally infected infants from Dar es Salaam, Tanzania, All three genomes had cross-over points with approximately the same genomic localization. The subtype C-Like sequences were located within pol, vif, vpr, vpu, the first exons of rev and tat, V3, and the U3-R regions of the LTR, Phylogenetic analyses of the full-length genomic sequences from these viruses showed the formation of a distinct subcluster on the HIV-1 subtype D branch, The pattern of recombination of genomes belonging to this new CRF, named CRF10_CD, might have resulted from independent recombination events occurring at high frequency or from a single source that originated earlier in this population. Future surveys will be needed to determine the potential of this CRF for epidemic spread.
引用
收藏
页码:423 / 431
页数:9
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