The evolution of ribonucleotide reduction revisited

被引：70

作者：

Stubbe, J ^{[1
]}

Ge, J ^{[1
]}

Yee, CS ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 02期

关键词：

D O I：

10.1016/S0968-0004(00)01764-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ribonucleotide reductases (RNRs) catalyze the conversion of both purine and pyrimidine nucleotides to deoxynucleotides in all organisms and provide all the monomeric precursors essential for both DNA replication and repair. RNRs have been divided into three classes on the basis of their unique metallo-cofactors. The exquisitely controlled free radical chemistry used by all RNRs, and the commonality of the structures of the subunits where the nucleotide reduction process occurs, together provide compelling evidence for the importance of chemistry in the divergent evolution of RNRs from a common progenitor.

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页码：93 / 99

页数：7

相关论文

共 47 条

[1] Allosteric regulation of the class III anaerobic ribonucleotide reductase from bacteriophage T4 [J].

Andersson, J ;

Westman, M ;

Hofer, A ;

Sjöberg, BM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (26) :19443-19448

[2] Cysteines involved in radical generation and catalysis of class III anaerobic ribonucleotide reductase -: A protein engineering study of bacteriophage T4 NrdD [J].

Andersson, J ;

Westman, M ;

Sahlin, M ;

Sjöberg, BM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (26) :19449-19455

[3] MECHANISM OF INACTIVATION OF ESCHERICHIA-COLI RIBONUCLEOTIDE REDUCTASE BY 2'-CHLORO-2'-DEOXYURIDINE 5'-DIPHOSPHATE - EVIDENCE FOR GENERATION OF A 2'-DEOXY-3'-KETONUCLEOTIDE VIA A NET 1,2 HYDROGEN SHIFT [J].

ATOR, MA ;

STUBBE, J .

BIOCHEMISTRY, 1985, 24 (25) :7214-7221

[4]

Becker A, 1999, NAT STRUCT BIOL, V6, P969

[5] COENZYME-B-12 DEPENDENT RIBONUCLEOTIDE REDUCTASE - EVIDENCE FOR THE PARTICIPATION OF 5 CYSTEINE RESIDUES IN RIBONUCLEOTIDE REDUCTION [J].

BOOKER, S ;

LICHT, S ;

BRODERICK, J ;

STUBBE, J .

BIOCHEMISTRY, 1994, 33 (42) :12676-12685

[6] ROLE OF EFFECTOR BINDING IN ALLOSTERIC CONTROL OF RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE [J].

BROWN, NC ;

REICHARD, P .

JOURNAL OF MOLECULAR BIOLOGY, 1969, 46 (01) :39-&

[7] Two conserved tyrosine residues in protein R1 participate in an intermolecular electron transfer in ribonucleotide reductase [J].

Ekberg, M ;

Sahlin, M ;

Eriksson, M ;

Sjoberg, BM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (34) :20655-20659

[8] Glycyl radical enzymes: a conservative structural basis for radicals [J].

Eklund, H ;

Fontecave, M .

STRUCTURE WITH FOLDING & DESIGN, 1999, 7 (11) :R257-R262

[9] Allosteric control of three B12-dependent (class II) ribonucleotide reductases -: Implications for the evolution of ribonucleotide reduction [J].

Eliasson, R ;

Pontis, E ;

Jordan, A ;

Reichard, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (11) :7182-7189

[10]

ELIASSON R, 1994, J BIOL CHEM, V269, P26052

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