A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

被引:7
作者
Gasse, C. [1 ]
Huteau, V. [1 ]
Douguet, D. [2 ]
Munier-Lehmann, H. [1 ]
Pochet, S. [1 ]
机构
[1] Inst Pasteur, Dept Biol Struct & Chim, CNRS, URA 2128,Unite Chim Organ, F-75724 Paris 15, France
[2] Univ Montpellier 1, INSERM, CNRS, CBS,U5048,U554, Montpellier, France
关键词
D O I
10.1080/15257770701513349
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
[No abstract available]
引用
收藏
页码:1057 / 1061
页数:5
相关论文
共 9 条
[1]
X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 Å resolution [J].
de la Sierra, IL ;
Munier-Lehmann, H ;
Gilles, AM ;
Bârzu, O ;
Delarue, M .
JOURNAL OF MOLECULAR BIOLOGY, 2001, 311 (01) :87-100
[2]
LEA3D: A computer-aided ligand design for structure-based drug design [J].
Douguet, D ;
Munier-Lehmann, H ;
Labesse, G ;
Pochet, S .
JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (07) :2457-2468
[3]
Mycobacterium tuberculosis thymidylate kinase:: Structural studies of intermediates along the reaction pathway [J].
Fioravanti, E ;
Haouz, A ;
Ursby, T ;
Munier-Lehmann, H ;
Delarue, M ;
Bourgeois, D .
JOURNAL OF MOLECULAR BIOLOGY, 2003, 327 (05) :1077-1092
[4]
Thymidylate kinase of Mycobacterium tuberculosis:: A chimera sharing properties common to eukaryotic and bacterial enzymes [J].
Munier-Lehmann, H ;
Chaffotte, A ;
Pochet, S ;
Labesse, G .
PROTEIN SCIENCE, 2001, 10 (06) :1195-1205
[5]
Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans [J].
Pochet, S ;
Dugué, L ;
Labesse, G ;
Delepierre, M ;
Munier-Lehmann, H .
CHEMBIOCHEM, 2003, 4 (08) :742-747
[6]
Pochet S, 2002, CHEMBIOCHEM, V3, P108, DOI 10.1002/1439-7633(20020104)3:1<108::AID-CBIC108>3.0.CO
[7]
2-B
[8]
3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase [J].
Vanheusden, V ;
Munier-Lehmann, H ;
Froeyen, M ;
Dugué, L ;
Heyerick, A ;
De Keukeleire, D ;
Pochet, S ;
Busson, R ;
Herdewijn, P ;
Van Calenbergh, S .
JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (18) :3811-3821
[9]
Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase [J].
Vanheusden, V ;
Munier-Lehmann, H ;
Pochet, S ;
Herdewijn, P ;
Van Calenbergh, S .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (19) :2695-2698