Stability of the Regulatory T Cell Lineage in Vivo

被引：555

作者：

Rubtsov, Yuri P. ^{[1
,2
]}

Niec, Rachel E. ^{[1
,2
]}

Josefowicz, Steven ^{[1
,2
]}

Li, Li ^{[3
]}

Darce, Jaime ^{[3
]}

Mathis, Diane ^{[3
]}

Benoist, Christophe ^{[3
]}

Rudensky, Alexander Y. ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

[3] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

SCIENCE | 2010年 / 329卷 / 5999期

关键词：

TRANSCRIPTION FACTOR FOXP3; DIFFERENTIATION; SELF; AUTOIMMUNITY; HOMEOSTASIS; GENERATION; INDUCTION; ORIGIN;

D O I：

10.1126/science.1191996

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tissue maintenance and homeostasis can be achieved through the replacement of dying cells by differentiating precursors or self-renewal of terminally differentiated cells or relies heavily on cellular longevity in poorly regenerating tissues. Regulatory T cells (T(reg) cells) represent an actively dividing cell population with critical function in suppression of lethal immune-mediated inflammation. The plasticity of T(reg) cells has been actively debated because it could factor importantly in protective immunity or autoimmunity. By using inducible labeling and tracking of T(reg) cell fate in vivo, or transfers of highly purified T(reg) cells, we have demonstrated notable stability of this cell population under physiologic and inflammatory conditions. Our results suggest that self-renewal of mature T(reg) cells serves as a major mechanism of maintenance of the T(reg) cell lineage in adult mice.

引用

页码：1667 / 1671

页数：6

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