Assessing the relationship between perfluoroalkyl substances, thyroid hormones and binding proteins in pregnant women; a longitudinal mixed effects approach

被引：83

作者：

Berg, Vivian ^{[1
,2
,3
]}

Nost, Therese Haugdahl ^{[1
,2
,3
]}

Hansen, Solrunn ^{[3
]}

Elverland, Astrid ^{[1
]}

Veyhe, Anna-Sofia ^{[3
]}

Jorde, Rolf ^{[4
]}

Odland, Jon Oyvind ^{[3
]}

Sandanger, Torkjel Manning ^{[2
,3
]}

机构：

[1] Univ Hosp Northern Norway, Dept Lab Med, Diagnost Clin, NO-9038 Tromso, Norway

[2] NILU Norwegian Inst Air Res, Fram Ctr, Dept Environm Chem, NO-296 Tromso, Norway

[3] Univ Tromso Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, NO-019 Tromso, Norway

[4] Univ Tromso Arctic Univ Norway, Inst Clin Med, Endocrine Res Grp, NO-9019 Tromso, Norway

来源：

ENVIRONMENT INTERNATIONAL | 2015年 / 77卷

关键词：

Thyroid hormones; Perfluoroallcyl substances; Pregnant women; Thyroxin binding capacity; Endocrine disruption; PERFLUOROOCTANE SULFONATE; POLYFLUOROALKYL SUBSTANCES; WHOLE-BLOOD; EXPOSURE; ACIDS; PFASS; HYPOTHYROXINEMIA; ORGANOCHLORINES; ASSOCIATIONS; SAMPLES;

D O I：

10.1016/j.envint.2015.01.007

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

The mechanisms involved in thyroid homeostasis are complex, and perfluoroalkyl substances (PFASs) have been indicated to interfere at several levels in this endocrine system. Disruption of the maternal thyroid homeostasis during early pregnancy is of particular concern, where subclinical changes in maternal thyroid hormones (THs) may affect embryonic and foetal development. The present study investigated associations between THs, thyroid binding proteins (TH-BPs) and PFAS concentrations in pregnant women from Northern Norway. Women participating in The Northern Norway Mother-and-Child contaminant Cohort Study (MISA) donated a blood sample at three visits related to their pregnancy and postpartum period (during the second trimester, 3 days and 6 weeks after delivery) in the period 2007-2009. Participants were assigned to quartiles according to PFAS concentrations during the second trimester and mixed effects linear models were used to investigate potential associations between PFASs and repeated measurements of TI-Is, TH-BPs, thyroxin binding capacity and thyroid peroxidase antibodies (anti-TP05). Women within the highest perfluorooctane sulfonate (PFOS) quartile had 24% higher mean concentrations of thyroid stimulating hormone (TSH) compared to the first quartile at all sampling points. Women within the highest quartiles of perfluorodecanoate (PFDA) had 4% lower mean concentrations of triiodothyronine (T3) and women within the highest quartile of perfluoroundecanoate (PFUnDA) had 3% lower mean concentrations of free triiodothyronine (FT3). Further, the difference in concentrations and the changes between three time points were the same for the PFAS quartiles. Thyroxin binding capacity was associated with all the THs and TH-BPs, and was selected as a holistic adjustment for individual changes in TH homeostasis during pregnancy. Finally, adjusting for maternal iodine status did not influence the model predictions. Findings in the present study suggest modifications of TH homeostasis by PFASs in a background exposed maternal population. The variation in levels of THs between PFAS quartiles was within normal reference ranges and may not be of clinical significance in the pregnant woman. However, subtle individual changes in maternal THs may have significant consequences for foetal health. 2015 Elsevier Ltd. All rights reserved.

引用

页码：63 / 69

页数：7

共 39 条

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Intra- and intercompartmental associations between levels of organochlorines in maternal plasma, cord plasma and breast milk, and lead and cadmium in whole blood, for indigenous peoples of Chukotka, Russia [J].