Finding schizophrenia genes

被引：91

作者：

Kirov, G ^{[1
]}

O'Donovan, MC ^{[1
]}

Owen, MJ ^{[1
]}

机构：

[1] Univ Cardiff Wales, Wales Coll Med, Dept Psychol Med, Cardiff CF14 4XN, Wales

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1172/JCI24759

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified a number of potential regions of linkage and 2 associated chromosomal abnormalities, and accumulating evidence favors several positional candidate genes. These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it.

引用

页码：1440 / 1448

页数：9

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