Minireview:: Tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology

被引:169
作者
Butler, AA
LeRoith, D
机构
[1] NIDDK, NIH, Clin Endocrinol Branch, Bethesda, MD 20892 USA
[2] Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97201 USA
关键词
D O I
10.1210/en.142.5.1685
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
The insulin-like growth factors (IGF-I and IGF-II) and the IGF-I receptor are critically important for normal growth and development of the organism. Gene-deletion of these elements has demonstrated that IGF-I is important for both prenatal and postnatal development, whereas IGF-II is important during prenatal stages only. The IGF-I receptor gene-deleted mouse dies at birth apparently as a result of poor muscular development. Utilizing the conditional gene-deletion approach, we have demonstrated that mice lacking the liver IGF-I gene have an approximately 80% reduction in circulating total IGF-I levels. Despite this marked reduction, postnatal growth and development was normal, suggesting that liver IGF-I is not essential for this function. Local tissue IGF-I production was unaffected and may compensate for the lack of the liver IGF-I. Further studies are ongoing to establish the role of the endocrine us, the autocrine/paracrine IGF-I.
引用
收藏
页码:1685 / 1688
页数:4
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