Multimarker Panels in Sepsis

被引：28

作者：

Casserly, Brian ^{[1
]}

Read, Richard ^{[2
]}

Levy, Mitchell M. ^{[2
]}

机构：

[1] Mem Hosp Rhode Isl, Div Pulm & Crit Care Med, Pawtucket, RI USA

[2] Brown Univ, Rhode Isl Hosp, Alpert Med Sch, Providence, RI 02903 USA

来源：

CRITICAL CARE CLINICS | 2011年 / 27卷 / 02期

关键词：

Multimarker panels; Sepsis; Biomarkers; Statistics; Systemic inflammatory response syndrome; INFLAMMATORY RESPONSE SYNDROME; CRITICALLY-ILL PATIENTS; SYSTEMIC INFLAMMATION; STATISTICAL-ANALYSIS; BIOMARKER PANEL; SEPTIC SHOCK; PROCALCITONIN; RISK; PROTEOMICS; VALIDATION;

D O I：

10.1016/j.ccc.2010.12.011

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Biomarkers differentiate between 2 or more biologic states. The complexity of diseases like sepsis makes it unlikely that any single marker will allow for precise disease specification. Combining several biomarkers into a single classification rule should help to improve their accuracy and, therefore, their usefulness. This article reviews several studies using multimarker panels, and highlights the potential of more sophisticated diagnostic and prognostic techniques in future multimarker panels. More complex algorithms should accelerate the adoption of multimarker panels into the routine management of patients with sepsis, provided that clinicians understand the multimarker approach.

引用

页码：391 / +

页数：16

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