Enzymatic N-terminal addition of noncanonical amino acids to peptides and proteins

被引：25

作者：

Connor, Rebecca E. ^{[1
]}

Piatkov, Konstantin ^{[2
]}

Varshavsky, Alexander ^{[2
]}

Tirrell, David A. ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

[2] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

CHEMBIOCHEM | 2008年 / 9卷 / 03期

关键词：

amino acids; peptides; proteins; transferases;

D O I：

10.1002/cbic.200700605

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：366 / 369

页数：4

共 33 条

[1] N-terminally PEGylated human interferon-β-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model [J].

Baker, DP ;

Lin, EY ;

Lin, K ;

Pellegrini, M ;

Petter, RC ;

Chen, LL ;

Arduini, RM ;

Brickelmaier, M ;

Wen, DY ;

Hess, DM ;

Chen, LQ ;

Grant, D ;

Whitty, A ;

Gill, A ;

Lindner, DJ ;

Pepinsky, RB .

BIOCONJUGATE CHEMISTRY, 2006, 17 (01) :179-188

[2] An efficient system for high-level expression and easy purification of authentic recombinant proteins [J].

Catanzariti, AM ;

Soboleva, TA ;

Jans, DA ;

Board, PG ;

Baker, RT .

PROTEIN SCIENCE, 2004, 13 (05) :1331-1339

[3] A designed phenylalanyl-tRNA synthetase variant allows efficient in vivo incorporation of aryl ketone functionality into proteins [J].

Datta, D ;

Wang, P ;

Carrico, IS ;

Mayo, SL ;

Tirrell, DA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (20) :5652-5653

[4] N-TERMINAL MODIFICATION OF PROTEINS - A REVIEW [J].

DIXON, HBF .

JOURNAL OF PROTEIN CHEMISTRY, 1984, 3 (01) :99-108

[5] ClpS is an essential component of the N-end rule pathway in Escherichia coli [J].

Erbse, A ;

Schmidt, R ;

Bornemann, T ;

Schneider-Mergener, J ;

Mogk, A ;

Zahn, R ;

Dougan, DA ;

Bukau, B .

NATURE, 2006, 439 (7077) :753-756

[6] Site-specific attachment of functionalized poly(ethylene glycol) to the amino terminus of proteins [J].

Gaertner, HF ;

Offord, RE .

BIOCONJUGATE CHEMISTRY, 1996, 7 (01) :38-44

[7] SITE-DIRECTED CONJUGATION OF NONPEPTIDE GROUPS TO PEPTIDES AND PROTEINS VIA PERIODATE-OXIDATION OF A 2-AMINO ALCOHOL - APPLICATION TO MODIFICATION AT N-TERMINAL SERINE [J].

GEOGHEGAN, KF ;

STROH, JG .

BIOCONJUGATE CHEMISTRY, 1992, 3 (02) :138-146

[8]

Gilmore J. M., 2006, Angew. Chem. Int. Edit, V118, P5433, DOI DOI 10.1002/ANGE.200600368

[9] N-terminal protein modification through a biomimetic transamination reaction [J].

Gilmore, Joshua M. ;

Scheck, Rebecca A. ;

Esser-Kahn, Aaron P. ;

Joshi, Neel S. ;

Francis, Matthew B. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (32) :5307-5311

[10] Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen [J].

Graciet, E ;

Hu, RG ;

Piatkov, K ;

Rhee, JH ;

Schwarz, EM ;

Varshavsky, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (09) :3078-3083

← 1 2 3 4 →