Reading TE leaves: New approaches to the identification of transposable element insertions

被引:83
作者
Ray, David A. [2 ]
Batzer, Mark A. [1 ]
机构
[1] Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA 70803 USA
[2] Mississippi State Univ, Dept Biochem & Mol Biol, Mississippi State, MS 39762 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
POPULATION GENETIC-STRUCTURE; CHROMOSOME REARRANGEMENTS; LINE-1; RETROTRANSPOSITION; L1; MOLECULAR EVIDENCE; ALU REPEATS; PHYLOGENETIC-RELATIONSHIPS; INTERSPERSED REPEATS; RETROPOSON ANALYSIS; ANTISENSE PROMOTER;
D O I
10.1101/gr.110528.110
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Transposable elements (TEs) are a tremendous source of genome instability and genetic variation. Of particular interest to investigators of human biology and human evolution are retrotransposon insertions that are recent and/or polymorphic in the human population. As a consequence, the ability to assay large numbers of polymorphic TEs in a given genome is valuable. Five recent manuscripts each propose methods to scan whole human genomes to identify, map, and, in some cases, genotype polymorphic retrotransposon insertions in multiple human genomes simultaneously. These technologies promise to revolutionize our ability to analyze human genomes for TE-based variation important to studies of human variability and human disease. Furthermore, the approaches hold promise for researchers interested in nonhuman genomic variability. Herein, we explore the methods reported in the manuscripts and discuss their applications to aspects of human biology and the biology of other organisms.
引用
收藏
页码:813 / 820
页数:8
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