Antidepressant effect of an ethanolic extract of the leaves of Cissampelos sympodialis in rats and mice

被引：27

作者：

Almeida, RN ^{[1
]}

Navarro, DS ^{[1
]}

de Assis, TS ^{[1
]}

de Medeiros, IA ^{[1
]}

Thomas, G ^{[1
]}

机构：

[1] Univ Fed Paraiba, Lab Tecnol Farmaceut, BR-58051970 Joao Pessoa, Paraiba, Brazil

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1998年 / 63卷 / 03期

关键词：

Cissampelos sympodialis; Menispermaceae; antidepressant effect; ethanolic extract;

D O I：

10.1016/S0378-8741(98)00086-5

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

An ethanolic extract of the leaves of Cissampelos sympodialis Eichl. (Menispermaceae) was found to potentiate the toxicity of pentylenetetrazol in mice. Similar to imipramine, the extract also reduced the immobility period in the forced swimming test in mice and reversed the degree of ptosis and catalepsy induced by reserpine in rats. These results suggest that the extract possesses antidepressant activity and the reported phosphodiesterase inhibitory activity of the plant may account for the observed antidepressant effect. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：247 / 252

页数：6

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