Towards a dengue vaccine: Progress to date and remaining challenges

被引：37

作者：

Guy, Bruno ^{[1
]}

Almond, Jeffrey W. ^{[1
]}

机构：

[1] Sanofi Pasteur, F-69280 Marcy Letoile, France

来源：

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 2008年 / 31卷 / 2-3期

关键词：

dengue; vaccine; clinical trials; antibodies; cellular immunity; vaccine safety;

D O I：

10.1016/j.cimid.2007.07.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The increased incidence and extended geographical reach of Dengue virus over the past two decades have made the development of an effective vaccine an international urgency. Various strategies are being pursued, including live, vectored and killed/recombinant preparations. For all approaches, the challenge is to induce a broad durable immune response against all four serotypes of Dengue virus simultaneously whilst avoiding the possible exacerbation of risk of developing the severe forms of disease through incomplete or modified responses. This review presents the current state of knowledge and discusses the challenges of further clinical development. (C) 2007 Elsevier Ltd. All rights reserved.

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页码：239 / 252

页数：14

相关论文

共 46 条

[1] Cross-protective immunity can account for the alternating epidemic pattern of dengue virus serotypes circulating in Bangkok [J].

Adams, B. ;

Holmes, E. C. ;

Zhang, C. ;

Mammen, M. P., Jr. ;

Nimmannitya, S. ;

Kalayanarooj, S. ;

Boots, M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14234-14239

[2]

Almond Jeffrey, 2002, Vaccine, V20, P3043, DOI 10.1016/S0264-410X(02)00246-3

[3] Tetravalent neutralizing antibody response against four dengue serotypes by a single chimeric dengue envelope antigen [J].

Apt, D ;

Raviprakash, K ;

Brinkman, A ;

Semyonov, A ;

Yang, SM ;

Skinner, C ;

Diehl, L ;

Lyons, R ;

Porter, K ;

Punnonen, J .

VACCINE, 2006, 24 (03) :335-344

[4] Development of a live attenuated dengue virus vaccine using reverse genetics [J].

Blaney, JE ;

Durbin, AP ;

Murphy, BR ;

Whitehead, SS .

VIRAL IMMUNOLOGY, 2006, 19 (01) :10-32

[5] Short report: Immune response and occurrence of dengue infection in thai children three to eight years after vaccination with live attenuated tetravalent dengue vaccine [J].

Chanthavanich, Pornthep ;

Luxemburger, Christine ;

Sirivichayakul, Chukiat ;

Lapphra, Keswadee ;

Pengsaa, Krisana ;

Yoksan, Sutee ;

Sabchareon, Arunee ;

Lang, Jean .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2006, 75 (01) :26-28

[6] Innate immune responses in human dendritic cells upon infection by chimeric yellow-fever dengue vaccine serotypes 1-4 [J].

Deauvieau, Florence ;

Sanchez, Violette ;

Balas, Claire ;

Kennel, Audrey ;

De Montfort, Aymeric ;

Lang, Jean ;

Guy, Bruno .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2007, 76 (01) :144-154

[7] The WHO dengue classification and case definitions: time for a reassessment [J].

Deen, Jacqueline L. ;

Harris, Eva ;

Wills, Bridget ;

Balmaseda, Angel ;

Hammond, Samantha Nadia ;

Rocha, Crisanta ;

Dung, Nguyen Minh ;

Hung, Nguyen Thanh ;

Hien, Tran Tinh ;

Farrar, Jeremy J. .

LANCET, 2006, 368 (9530) :170-173

[8] Modification of dengue virus strains by passage in primary dog kidney cells: Preparation of candidate vaccines and immunization of monkeys [J].

Eckels, KH ;

Dubois, DR ;

Putnak, R ;

Vaughn, DW ;

Innis, BL ;

Henchal, EA ;

Hoke, CH .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2003, 69 (06) :12-16

[9] Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand [J].

Endy, TP ;

Nisalak, A ;

Chunsuttitwat, S ;

Vaughn, DW ;

Green, S ;

Ennis, FA ;

Rothman, AL ;

Libraty, DH .

JOURNAL OF INFECTIOUS DISEASES, 2004, 189 (06) :990-1000

[10] Immunopathological mechanisms in dengue and dengue hemorrhagic fever [J].

Green, Sharone ;

Rothman, Alan .

CURRENT OPINION IN INFECTIOUS DISEASES, 2006, 19 (05) :429-436

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