Caspase deficiency alters the murine gut microbiome

被引：71

作者：

Brinkman, B. M. ^{[2
,3
]}

Hildebrand, F. ^{[1
]}

Kubica, M. ^{[2
,3
]}

Goosens, D. ^{[4
,5
]}

del Favero, J. ^{[4
,5
]}

Declercq, W. ^{[2
,3
]}

Raes, J. ^{[1
]}

Vandenabeele, P. ^{[2
,3
]}

机构：

[1] Vrije Univ Brussel, VIB, Dept Mol & Cellular Interact, B-1050 Brussels, Belgium

[2] VIB, Dept Mol Biomed Res, Ghent, Belgium

[3] Univ Ghent, Dept Mol Biomed Res, B-9000 Ghent, Belgium

[4] VIB Dept Mol Genet, Antwerp, Belgium

[5] Univ Antwerp, Dept Mol Genet, B-2020 Antwerp, Belgium

来源：

CELL DEATH & DISEASE | 2011年 / 2卷

关键词：

caspase-1; caspase-3; caspase-7; knockout; gut microbiome; pyrosequencing; CHAIN FATTY-ACIDS; IL-1-BETA-CONVERTING ENZYME; DEFENSE; MICE;

D O I：

10.1038/cddis.2011.101

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Caspases are aspartate-specific cysteine proteases that have an essential role in apoptosis and inflammation, and contribute to the maintenance of homeostasis in the intestine. These facts, together with the knowledge that caspases are implicated in host-microbe crosstalk, prompted us to investigate the effect of caspase (Casp) 1, -3 and -7 deficiency on the composition of the murine gut microbiota. We observed significant changes in the abundance of the Firmicutes and Bacteroidetes phyla, in particular the Lachnospiraceae, Porphyromonodaceae and Prevotellacea families, when comparing Casp-1, -7 and -3 knockout mice with wild-type mice. Our data point toward an intricate relationship between these caspases and the composition of the murine gut microflora. Cell Death and Disease (2011) 2, e220; doi: 10.1038/cddis.2011.101; published online 20 September 2011

引用

页码：e220 / e220

页数：6

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