Reagent-controlled domino synthesis of skeletally-diverse compound collections

被引：42

作者：

Waldmann, Herbert ^{[1
,2
]}

Kuehn, Marc ^{[1
,2
]}

Liu, Wei ^{[1
,2
]}

Kumar, Kamal ^{[1
,2
]}

机构：

[1] Max Planck Inst Mol Physiol, Abt Chem Biol, D-44227 Dortmund, Germany

[2] Univ Dortmund, Fachbereich 3, D-44227 Dortmund, Germany

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 10期

关键词：

D O I：

10.1039/b717635j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient reagent-controlled methodology for generating highly substituted diverse scaffolds from a common substrate has been developed; thus, treatment of a common precursor with different desilylating reagents, such as ammonium fluoride, caesium fluoride and PPTS, triggers different domino reaction sequences, yielding highly substituted pyridines, phenols and benzopyrans, respectively; the substituent patterns of these scaffolds provide further opportunities for library development.

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收藏

页码：1211 / 1213

页数：3

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