Kinetic and catalytic mechanisms of protein kinases

被引：484

作者：

Adams, JA ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

来源：

CHEMICAL REVIEWS | 2001年 / 101卷 / 08期

关键词：

D O I：

10.1021/cr000230w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The kinetic and catalytic mechanisms of protein kinases which regulated carbohydrate and lipid metabolism processes were discussed. The roles of active-site residues, metal ions, conformational changes and regulatory phosphorylation on the processing of peptide and protein substrates were also investigated. It was found that the phosphorylation of protein kinase was complex and involved structural changes.

引用

页码：2271 / 2290

页数：20

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