Iron overload upregulates haem oxygenase 1 in the lung more rapidly than in other tissues

被引：22

作者：

Anning, PB ^{[1
]}

Chen, Y ^{[1
]}

Lamb, NJ ^{[1
]}

Mumby, S ^{[1
]}

Quinlan, GJ ^{[1
]}

Evans, TW ^{[1
]}

Gutteridge, JMC ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Royal Brompton & Harefield NHS Trust, Crit Care Unit, London SW3, England

来源：

FEBS LETTERS | 1999年 / 447卷 / 01期

关键词：

haem oxygenase; oxidant damage; iron;

D O I：

10.1016/S0014-5793(99)00250-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Haem oxygenase-l is upregulated by numerous insults, including oxidative stress, and under such circumstances it is considered to be a protective stratagem. We have measured the haem oxygenase-l expression in heart, lung and liver tissues of control and iron-overloaded rats. Lung tissue from iron-overloaded rats displayed a significant increase in the haem oxygenase-l protein but no changes in haem oxygenase-l mRNA, Conversely, heart tissue showed a significant increase in haem oxygenase-l mRNA but no changes in haem oxygenase-1 protein. We conclude that during oxidative stress caused by iron overload, lung tissue responds with a rapid upregulation of haem oxygenase-l levels. (C) 1999 Federation of European Biochemical Societies.

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页码：111 / 114

页数：4

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