Drug discovery for hyperuricemia

被引：22

作者：

Anzai, Naohiko ^{[1
]}

Endou, Hitoshi ^{[1
]}

机构：

[1] Kyorin Univ, Sch Med, Dept Pharmacol & Toxicol, Mitaka, Tokyo 1818611, Japan

来源：

EXPERT OPINION ON DRUG DISCOVERY | 2007年 / 2卷 / 09期

基金：

日本学术振兴会;

关键词：

CFEX; hyperuricemia; PDZK1; SMCT; URAT1; urate;

D O I：

10.1517/17460441.2.9.1251

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hyperuricemia is associated with an increased risk of developing gout. This increases with the degree and duration of hyperuricemia. Gout can be managed by dietary modification and pharmacologic urate-lowering therapies. The recent identification of the renal apical urate/anion exchanger URAT1 (SLC22A12) and several membrane proteins relevant to the transport of urate play an important role in gaining a better understanding of the mode of action of many drugs used to treat gout. As described in this review, therapeutics designed to modify URAT1 transport activities might be useful in treating pathologies associated with hyperuricemia such as gout and urolithiasis. Continuing studies into the urate transportsome hold promise for the development of new, more effective therapeutics for hyperuricemia.

引用

页码：1251 / 1261

页数：11

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