Sentinel hospital surveillance for rotavirus diarrhea in the People's Republic of China, August 2001 July 2003

被引:75
作者
Fang, ZY
Wang, B
Kilgore, PE
Bresee, JS
Zhang, LJ
Sun, LW
Du, ZQ
Tang, JY
Hou, AC
Shen, H
Song, XB
Nyambat, B
Hummelman, E
Xu, ZY
Glass, RI
机构
[1] Chinese Ctr Dis Control & Prevent, Viral Gastroenteritis Div, Natl Inst Viral Dis Control & Prevent, Beijing 100052, Peoples R China
[2] Beijing Friendship Hosp, Dept Pediat, Beijing, Peoples R China
[3] Dongnan Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Nanjing, Peoples R China
[4] Changchun Childrens Hosp, Dept Med Res, Changchun, Jilin Prov, Peoples R China
[5] Kunming Childrens Hosp, Dept Infect Dis, Kunming, Yunnan Prov, Peoples R China
[6] Suzhou Municipal Ctr Dis Control & Prevent, Suzhou, Jiangsu Prov, Peoples R China
[7] Maanshan Steel & Iron Trust Hosp, Dept Pediat, Maanshan, Anhui, Peoples R China
[8] Int Vaccine Inst, Div Translat Res, Seoul, South Korea
[9] Ctr Dis Control & Prevent, Resp & Enter Viruses Branch, Div Viral & Rickettsial Dis, Atlanta, GA USA
关键词
D O I
10.1086/431505
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
China has the second largest birth cohort in the world and the second highest number of deaths due to rotavirus infection. It is also the only country with a licensed rotavirus vaccine. Chinese policy makers now need credible estimates of the burden of rotavirus disease, to decide about vaccine use. From August 2001 through July 2003, prospective hospital-based surveillance for rotavirus diarrhea among children ! 5 years of age was conducted in 6 sentinel hospitals. Rotavirus isolates were characterized to determine the G and P genotypes circulating during the study. Of 3149 children who were admitted to the hospitals for diarrhea and for whom screening for rotavirus was performed, 1590 (50%) had positive results of an antigen detection assay. Of all episodes of rotavirus diarrhea, 95% occurred during the first 2 years of life. The most common rotavirus strain was P[8]G3 (49% of episodes), and all the common strains were detected, including G9 strains (4% of episodes). Ongoing efforts are under way to more precisely define the burden of rotavirus diarrhea in urban and rural populations, to assess the proportion of episodes that may be due to unusual or emerging strains, and to estimate the economic burden of rotavirus disease.
引用
收藏
页码:S94 / S99
页数:6
相关论文
共 19 条
[1]   Etiology of acute gastroenteritis in hospitalized children in Melbourne, Australia, from April 1980 to March 1993 [J].
Barnes, GL ;
Uren, E ;
Stevens, KB ;
Bishop, RF .
JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (01) :133-138
[2]   First report from the Asian rotavirus surveillance network [J].
Bresee, J ;
Fang, ZY ;
Wang, B ;
Nelson, EAS ;
Tam, J ;
Soenarto, Y ;
Wilopo, SA ;
Kilgore, P ;
Kim, JS ;
Kang, JO ;
Lan, WS ;
Gaik, CL ;
Moe, K ;
Chen, KT ;
Jiraphongsa, C ;
Pongsuwanna, Y ;
Van Man, N ;
Van Tu, P ;
Luan, LT ;
Hummelman, E ;
Gentsch, JR ;
Glass, R .
EMERGING INFECTIOUS DISEASES, 2004, 10 (06) :988-995
[3]  
CHEN YH, 1992, J 1 MED COLLEGE PLA, V12, P363
[4]   Public health considerations for the introduction of new rotavirus vaccines for infants: A case study of tetravalent rhesus rotavirus-based reassortant vaccine [J].
Clemens, J ;
Keckich, N ;
Naficy, A ;
Glass, R ;
Rao, M .
EPIDEMIOLOGIC REVIEWS, 1999, 21 (01) :24-42
[5]   Diversity of rotavirus strains among children with acute diarrhea in China: 1998-2000 surveillance study [J].
Fang, ZY ;
Yang, H ;
Qi, J ;
Zhang, J ;
Sun, LW ;
Tang, JY ;
Ma, L ;
Du, ZQ ;
He, AH ;
Xie, JP ;
Lu, YY ;
Ji, ZZ ;
Zhu, BQ ;
Wu, HY ;
Lin, SE ;
Xie, HP ;
Griffin, DD ;
Ivanoff, B ;
Glass, RI ;
Gentsch, JR .
JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (05) :1875-1878
[6]   Child rotavirus infection in association with acute gastroenteritis in two Chinese sentinel hospitals [J].
Fang, ZY ;
Yang, H ;
Zhang, J ;
Li, YF ;
Hou, AC ;
Ma, L ;
Sun, LW ;
Wang, CX .
PEDIATRICS INTERNATIONAL, 2000, 42 (04) :401-405
[7]  
Fleiss JL., 1981, STAT METHODS RATES P, P14
[8]   IDENTIFICATION OF GROUP-A ROTAVIRUS GENE-4 TYPES BY POLYMERASE CHAIN-REACTION [J].
GENTSCH, JR ;
GLASS, RI ;
WOODS, P ;
GOUVEA, V ;
GORZIGLIA, M ;
FLORES, J ;
DAS, BK ;
BHAN, MK .
JOURNAL OF CLINICAL MICROBIOLOGY, 1992, 30 (06) :1365-1373
[9]   Review of G and P typing results from a global collection of rotavirus strains: Implications for vaccine development [J].
Gentsch, JR ;
Woods, PA ;
Ramachandran, M ;
Das, BK ;
Leite, JP ;
Alfieri, A ;
Kumar, R ;
Bhan, MK ;
Glass, RI .
JOURNAL OF INFECTIOUS DISEASES, 1996, 174 :S30-S36
[10]   The epidemiology of rotavirus diarrhea in the United States: Surveillance and estimates of disease burden [J].
Glass, RI ;
Kilgore, PE ;
Holman, RC ;
Jin, SX ;
Smith, JC ;
Woods, PA ;
Clarke, MJ ;
Ho, MS ;
Gentsch, JR .
JOURNAL OF INFECTIOUS DISEASES, 1996, 174 :S5-S11