Gerosuppressant Metformin: less is more

被引：52

作者：

Menendez, Javier A. ^{[1
,2
]}

Cufi, Silvia ^{[1
,2
]}

Oliveras-Ferraros, Cristina ^{[1
,2
]}

Vellon, Luciano ^{[3
]}

Joven, Jorge ^{[4
]}

Vazquez-Martin, Alejandro ^{[1
,2
]}

机构：

[1] Catalan Inst Oncol, Girona, Catalonia, Spain

[2] Girona Biomed Res Inst, Girona, Catalonia, Spain

[3] Fdn INBIOMED, Cell Reprogramming Unit, San Sebastian, Basque Country, Spain

[4] Univ Rovira & Virgili, Inst Invest Sanitaria Pere Virgili, Hosp Univ St Joan Reus, Ctr Recerca Biomed, E-43201 Reus, Catalonia, Spain

来源：

AGING-US | 2011年 / 3卷 / 04期

关键词：

ANTIDIABETIC DRUG METFORMIN; FATTY-ACID SYNTHASE; DNA-DAMAGE RESPONSE; EXTENDS LIFE-SPAN; CALORIE RESTRICTION MIMETICS; MESENCHYMAL TRANSITION EMT; TERM DIETARY RESTRICTION; BREAST-CANCER RESISTANCE; CELL-CYCLE ARREST; HIGH-ENERGY DIET;

D O I：

10.18632/aging.100316

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：348 / 362

页数：15

共 160 条

[1] Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth [J].

Algire, Carolyn ;

Zakikhani, Mahvash ;

Blouin, Marie-Jose ;

Shuai, Jian Hua ;

Pollak, Michael .

[2] Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase [J].

Algire, Carolyn ;

Amrein, Lilian ;

Zakikhani, Mahvash ;

Panasci, Lawrence ;

Pollak, Michael .

[3] Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice [J].

Alli, PM ;

Pinn, ML ;

Jaffee, EM ;

McFadden, JM ;

Kuhajda, FP .

ONCOGENE, 2005, 24 (01) :39-46

[4] Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 Adipocytes - A role for oxidant stress (Publication with Expression of Concern. See vol. 294, pg. 10025, 2019) (Withdrawn Publication. See vol. 295, pg. 667, 2020) [J].

An, Zhibo ;

Wang, Hong ;

Song, Ping ;

Zhang, Miao ;

Geng, Xuemei ;

Zou, Ming-Hui .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (37) :26793-26801

[5] Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 levels [J].

Anedda, Andrea ;

Rial, Eduardo ;

Gonzalez-Barroso, M. Mar .

JOURNAL OF ENDOCRINOLOGY, 2008, 199 (01) :33-40

[6] Metformin slows down aging and extends life span of female SHR mice [J].

Anisimov, Vladimir N. ;

Berstein, Lev M. ;

Egormin, Peter A. ;

Piskunova, Tatiana S. ;

Popovich, Irina G. ;

Zabezhinski, Mark A. ;

Tyndyk, Margarita L. ;

Yurova, Maria V. ;

Kovalenko, Irina G. ;

Poroshina, Tatiana E. ;

Semenchenko, Anna V. .

CELL CYCLE, 2008, 7 (17) :2769-2773

[7] If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice [J].

Anisimov, Vladimir N. ;

Berstein, Lev M. ;

Popovich, Irina G. ;

Zabezhinski, Mark A. ;

Egormin, Peter A. ;

Piskunova, Tatiana S. ;

Semenchenko, Anna V. ;

Tyndyk, Margarita L. ;

Yurova, Maria N. ;

Kovalenko, Irina G. ;

Poroshina, Tatiana E. .

AGING-US, 2011, 3 (02) :148-157

[8] Metformin extends life span of HeR-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo [J].

Anisimov, Vladimir N. ;

Egormin, Peter A. ;

Piskunova, Tatiana S. ;

Popovich, Irina G. ;

Tyndyk, Margarita L. ;

Yurova, Maria N. ;

Zabezhinski, Mark A. ;

Anikin, Ivan V. ;

Karkach, Arseniy S. ;

Romanyukha, Alexey A. .

CELL CYCLE, 2010, 9 (01) :188-197

[9] Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice [J].

Anisimov, VN ;

Berstein, LM ;

Egormin, PA ;

Piskunova, TS ;

Popovich, IG ;

Zabezhinski, MA ;

Kovalenko, IG ;

Poroshina, TE ;

Semenchenko, AV ;

Provinciali, M ;

Re, F ;

Franceschi, C .

EXPERIMENTAL GERONTOLOGY, 2005, 40 (8-9) :685-693

[10] Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history:: A combined analysis of 22 studies [J].

Antoniou, A ;

Pharoah, PDP ;

Narod, S ;

Risch, HA ;

Eyfjord, JE ;

Hopper, JL ;

Loman, N ;

Olsson, H ;

Johannsson, O ;

Borg, Å ;

Pasini, B ;

Radice, P ;

Manoukian, S ;

Eccles, DM ;

Tang, N ;

Olah, E ;

Anton-Culver, H ;

Warner, E ;

Lubinski, J ;

Gronwald, J ;

Gorski, B ;

Tulinius, H ;

Thorlacius, S ;

Eerola, H ;

Nevanlinna, H ;

Syrjäkoski, K ;

Kallioniemi, OP ;

Thompson, D ;

Evans, C ;

Peto, J ;

Lalloo, F ;

Evans, DG ;

Easton, DF .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (05) :1117-1130

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