Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries

被引：150

作者：

Giladi, Amir ^{[1
]}

Amit, Ido ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

来源：

CELL | 2018年 / 172卷 / 1-2期

基金：

以色列科学基金会; 欧洲研究理事会;

关键词：

MONONUCLEAR PHAGOCYTE SYSTEM; INNATE LYMPHOID-CELLS; RNA-SEQ; GENE-EXPRESSION; SPATIAL RECONSTRUCTION; IMMUNE-SYSTEM; EPIGENETIC HETEROGENEITY; CHROMATIN ACCESSIBILITY; LINEAGE COMMITMENT; DIFFERENTIATION;

D O I：

10.1016/j.cell.2017.11.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The immunology field has invested great efforts and ingenuity to characterize the various immune cell types and elucidate their functions. However, accumulating evidence indicates that current technologies and classification schemes are limited in their ability to account for the functional heterogeneity of immune processes. Single-cell genomics hold the potential to revolutionize the way we characterize complex immune cell assemblies and study their spatial organization, dynamics, clonal distribution, pathways, function, and crosstalks. In this Perspective, we consider recent and forthcoming technological and analytical advances in single-cell genomics and the potential impact of those advances on the future of immunology research and immunotherapy.

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页码：14 / 21

页数：8

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