Regeneration beyond the glial scar

被引：2397

作者：

Silver, J ^{[1
]}

Miller, JH ^{[1
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2004年 / 5卷 / 02期

关键词：

D O I：

10.1038/nrn1326

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

After injury to the adult central nervous system (CNS), injured axons cannot regenerate past the lesion. In this review, we present evidence that this is due to the formation of a glial scar. Chondroitin and keratan sulphate proteoglycans are among the main inhibitory extracellular matrix molecules that are produced by reactive astrocytes in the glial scar, and they are believed to play a crucial part in regeneration failure. We will focus on this role, as well as considering the behaviour of regenerating neurons in the environment of CNS injury.

引用

页码：146 / 156

页数：11

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