Distribution of Helicobacter pylori in north China

被引：29

作者：

Gong, Yue-Hua ^{[1
]}

Wang, Ying ^{[1
]}

Yuan, Yuan ^{[1
]}

机构：

[1] China Med Univ, Affiliated Hosp 1, Inst Canc, Shenyang 110001, Liaoning Provin, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2005年 / 11卷 / 23期

关键词：

Helicobacter pylori; Gastric disease; cagA; vacA; iceA; Virulence genotype; High-risk area;

D O I：

10.3748/wjg.v11.i23.3523

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To compare the distribution of virulence-associated genotypes of Helicobacter pylori (H pylori) in two areas of north China with different gastric cancer risk and furthermore probe into the pathogenicity of the bacterium. METHODS: Gastric biopsies were taken from 355 subjects from Zhuanghe, a high risk area of gastric cancer, and 136 subjects from Shenyang, a low risk area of gastric cancer. A total of 149 H pylori strains isolated from these patients were studied by PCR for differences in the genotypes of cagA, vacA, and iceA. RESULTS: In patients with high risk for gastric cancer, higher frequencies of vacA s1 or s1m1b genotypes were found as compared to those from the low risk area. CONCLUSION: There is significantly different distribution of H pylori genotypes between Zhuanghe and Shenyang areas in north China. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

引用

页码：3523 / 3527

页数：5

共 23 条

[1]

DNA DIVERSITY AMONG CLINICAL ISOLATES OF HELICOBACTER-PYLORI DETECTED BY PCR-BASED RAPD FINGERPRINTING [J].